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Entrepreneuring in the Pharma Industry

Entrepreneuring in the Pharma Industry

In this episode, Brian Fiske, founder, and CSO at Mythic Therapeutics talks about the work Mythic does, the journey that led him to create the company, and what he has learned along the way.

After earning experience in the pharma industry, Brian wanted to start his own company and focus on making drugs for patients rather than on technology. At Mythic, he and his team looked at antibody-drug conjugates focusing on the antibody side to target affected cells. He discusses the importance of connecting with people at the company and work teams and interpreting their feedback. Brian also shares his thoughts on shipping and data management as challenges that, when addressed properly, can make drug development much more efficient.


Tune in to this episode to learn from Brian Fiske about the inner workings of Mythic Therapeutics in drug development!


Mythic is merging science and business for groundbreaking drug development.

About Brian Fiske:

Brian Fiske is one of the premier young entrepreneurs in biotech. In July 2017, he co-founded Mythic Therapeutics, a product-platform company developing a pipeline of antibody-drug conjugates (ADCs) designed to exhibit unparalleled therapeutic index and efficacy. He currently serves as the company’s Chief Scientific Officer and as a member of the Board of Directors. Mythic’s FateControl technology specifically enhances ADC uptake in targeted tissues by manipulating the fate of the ADC within the cell, thereby expanding the disease and patient profiles that can be treated with Mythic’s ADCs. Prior to Mythic, Brian was a co-founder and Chief Technology Officer at Ohana Biosciences and a Senior Associate at Flagship Ventures, where he co-founded Ohana and KSQ Therapeutics. In 2016, he was nationally recognized for healthcare entrepreneurship by Forbes 30 under 30. 

Before Flagship, Brian completed his Ph.D. in Biology in Matt Vander Heiden’s lab at MIT where he published over 10 papers in the field of cancer metabolism. He also worked closely with Agios Pharmaceuticals (NASDAQ: AGIO) on their cancer metabolism programs, which have since translated into 4 clinical programs including two approved drugs. Before his Ph.D., he worked at Bain & Company with pharmaceutical, hedge fund, and industrial clients. He holds an A.B. summa cum laude in Biochemical Sciences with a secondary field in Economics from Harvard University.

Things You’ll Learn:

  • Mythic Therapeutics ensures that the antibody molecule they use can kill the targeted tumor and not affect the normal tissues.
  • It is very hard to run a trial where you don’t own one of the drugs.
  • Mythic Therapeutics is the only company focusing on antibodies for antibody-drug conjugates.
  • There’s a lot of pressure as a small company to get your first drug out.
  • If you’re a company founder, engage with many people as early as possible, but try to understand what they’re trying to share with you and how you can apply it.

  • Connect with and follow Brian Fiske on LinkedIn.
  • Follow Mythic Therapeutics on LinkedIn.
  • Explore the Mythic Therapeutics Website!
  • Connect with and follow co-host Kerri Anderson on LinkedIn.

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